Unsupported Browser

Your web browser appears to be outdated. Our website may not look quite right in it.

Please consider updating your browser to enjoy an optimal experience.

Dismiss this message

Blog Image

Everything you should know about Spermidine Supplements


Many or all of the products featured here can be from partners who compensate us. This may influence which products we write about and where and how the product appears on a page. However, this does not influencer our evaluations. Our opinions are our own.

Spermidine supplements are a game changer. But first, we will talk about spermidine. Spermidine is a naturally occurring polyamine compound that is found in various living organisms, including plants, animals, and bacteria. It is involved in essential cellular processes and plays a role in regulating cell growth, differentiation, and survival. Here are some key points about spermidine:

Chemical Structure Polyamine
Natural Sources Wheat germ, soybeans, mushrooms, peas, aged cheese, certain fruits (grapefruit, oranges, bananas), and vegetables (broccoli, cauliflower)
Potential Benefits Autophagy induction, anti-aging effects, cardiovascular health support, neuroprotection, anti-inflammatory properties
Research Areas Aging research, neurodegenerative diseases, cardiovascular health, cancer, metabolic disorders
Cellular Function Regulates cell growth, proliferation, and survival
Autophagy Induction Enhances the body's cellular recycling and renewal process
Bioavailability Readily absorbed and distributed in the body
Dosage No established dosage guidelines, varies depending on the specific condition or purpose
Safety Generally considered safe when consumed as part of a balanced diet
Supplementation Spermidine supplements are available, but consulting with a healthcare professional is recommended
Potential Side Effects Limited evidence of side effects, high doses may cause gastrointestinal discomfort
Regulatory Status Considered a dietary supplement, not regulated as a drug
Additional Considerations Quality and sourcing of supplements, potential interactions with medications or other supplements
  1. Structure: Spermidine belongs to the polyamine family, which also includes spermine and putrescine. It consists of a flexible carbon backbone with four amino groups.

  2. Biological Functions: Spermidine is involved in multiple biological processes, including DNA and protein synthesis, cell proliferation, cell signaling, and apoptosis (programmed cell death).

  3. Antioxidant and Anti-aging Effects: Spermidine has been linked to potential antioxidant effects, protecting cells from oxidative stress and reducing cellular damage. It has also gained attention for its potential anti-aging properties, as studies have suggested that spermidine supplementation may extend the lifespan and improve the health span of various organisms.

  4. Autophagy Induction: Spermidine has been found to induce autophagy, a cellular recycling process that removes damaged or dysfunctional components, promotes cellular renewal, and maintains cellular health.

  5. Dietary Sources: Spermidine is present in varying amounts in different foods. It can be found in wheat germ, soybeans, mushrooms, peas, and some types of cheese. The content of spermidine in foods can depend on factors such as ripeness, storage conditions, and processing methods.

  6. Research and Health Potential: Research on spermidine is still ongoing, and its potential health benefits and mechanisms of action are still being explored. Preliminary studies suggest that spermidine may have implications in various areas, including cardiovascular health, neuroprotection, and cancer prevention. However, further research, including human clinical trials, is needed to confirm these potential benefits and determine optimal doses.

It's important to note that while spermidine shows promise in scientific research, it is not yet widely used as a therapeutic agent or dietary supplement. As with any new supplement or intervention, it's advisable to consult with a healthcare professional before considering spermidine supplementation, especially if you have underlying health conditions or are taking medications.

Do Spermindine Supplements exist?

Yes, spermidine supplements do exist. Due to the increasing interest in spermidine's potential health benefits, some companies have developed spermidine supplements that are available in the market. These supplements typically contain spermidine derived from natural sources or synthesized through laboratory processes.

Spermidine supplements are often marketed for their potential anti-aging and health-promoting effects. They may be available in various forms such as capsules, tablets, or powders. However, it's important to note that the efficacy, safety, and optimal dosage of spermidine supplements are still areas of ongoing research.

If you are considering spermidine supplementation, it is recommended to consult with a healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications. They can provide personalized guidance, evaluate potential interactions or contraindications, and help determine the most appropriate course of action based on your individual health needs and goals.

Additionally, when purchasing spermidine supplements, it's important to choose products from reputable manufacturers who adhere to good manufacturing practices and undergo rigorous testing for quality and purity. Ensuring the reliability and authenticity of the supplement is crucial for your safety and well-being.

Famous spermidine supplements

Here's a list of a few famous spermidine supplements:

Spermidine Supplement from Double Wood Supplements

Spermidine Supplement with 120 capsules


(10mg 99% Spermidine 3HCL - Third Party Tested) 120 capsules - over 100x stronger than wheat germ extract for cell membrane, telomere health, and aging due to double wood.

  • Pure 99% Spermidine Trihydrochloride: Double Wood's Spermidine offers exceptional potency, being more than 100 times stronger than competing Wheat Germ Extracts that contain only minimal amounts of Spermidine.
  • Verify the Supplement Fact Panel: Always review the supplement fact panel to determine the precise Spermidine content. Many wheat germ products from competitors fail to disclose Spermidine on their supplement fact panel.
  • Support for Healthy Aging: Spermidine plays a crucial role in maintaining cell membrane integrity and may contribute to cognitive function and overall health as we age.
  • Promotes Telomere Health: Spermidine is instrumental in the process of cellular renewal and may help preserve the length of telomeres, the protective caps on our chromosomes, as we grow older.
  • Proudly Made in the USA: Our Spermidine capsules are manufactured and tested in the USA. They are gluten-free, and we prioritize using non-GMO ingredients.

Spermidine Supplement from Yougn & Earth

Spermidine Supplement from Yougn & Earth

Youth & Earth's Spermidine supplement, an award-winning natural polyamine, is designed to combat aging and promote longevity by activating autophagy, the body's cellular renewal and recycling process.

  • Every second, approximately one million cells in our body die, and while our cells naturally regenerate, this process becomes less efficient as we age. Regulating and activating autophagy through Spermidine is crucial for maintaining optimal cell renewal.
  • Youth & Earth's Spermidine supplement is derived from buckwheat sprouts, which boast the highest concentration of Spermidine among all food sources at 3.5mg/g. This surpasses the Spermidine content of Natto and Wheatgerm, which stand at 1mg/g. Spermidine has long been recognized in Japanese culture for its purported anti-aging properties, supporting both lifespan and healthspan.
  • A diet rich in polyamines, including Spermidine, is believed to be one of the secrets behind the Okinawans' longevity in the Blue Zones, where individuals often live active lives well into their 90s and beyond. Okinawa is renowned as one of the world's healthiest places to reside, with women boasting an average life expectancy of 90 years.
  • Spermidine supplementation is also known to support hair health during the anagen phase and improve nail health.

Youth & Earth sources its Spermidine from Austria, where the concentration has been shown to be 350% higher compared to Wheatgerm-derived Spermidine.

Other brands

The list is endless because there are multiple suppliers.

What foods are great when one wants to supplement the body with spermidine?

Spermidine is naturally present in various foods, although the levels can vary. Here are some food sources that are relatively rich in spermidine:

  1. Wheat Germ: Wheat germ is known to have a high concentration of spermidine. It can be consumed as part of whole wheat products or as a separate supplement.

  2. Soybeans and Soy Products: Soybeans, as well as soy-based products like tofu and tempeh, contain significant amounts of spermidine.

  3. Mushrooms: Certain types of mushrooms, including shiitake, portobello, and white button mushrooms, are good sources of spermidine.

  4. Legumes: Lentils, chickpeas, and other legumes contain varying levels of spermidine. They can be included in soups, stews, salads, or as part of plant-based meals.

  5. Green Peas: Green peas are a nutritious vegetable that provides spermidine along with other beneficial nutrients.

  6. Corn: Corn, particularly the fresh variety, can also contain spermidine, though the levels may vary.

  7. Cheese: Some varieties of cheese, such as aged cheese, have been found to contain higher levels of spermidine.

Can over-supplementing spermidine become dangerous?

When taken at appropriate doses, spermidine is generally considered safe for most individuals. It is a naturally occurring compound found in various foods and is also produced in the body as part of normal metabolic processes. However, as with any dietary supplement or intervention, there are certain considerations to keep in mind:

  1. Dosage: The optimal dosage of spermidine supplementation has not been well established, and research is still ongoing. It's important to follow the recommended dosage instructions provided by the manufacturer or as advised by a healthcare professional. Taking excessive amounts of spermidine supplements may have unknown effects and could potentially lead to adverse reactions.

  2. Individual Variations: People may respond differently to supplements, including spermidine. Individual factors such as underlying health conditions, medication use, and personal sensitivities can influence how the body reacts to the supplement. It's advisable to consult with a healthcare professional before starting any new supplement, especially if you have specific health concerns or are taking medications.

  3. Allergies or Sensitivities: Some individuals may have allergies or sensitivities to specific food sources that contain spermidine, such as wheat germ or soy. If you have known allergies or sensitivities, it's important to read product labels carefully and check for any potential allergens or ingredients that may cause adverse reactions.

  4. Interaction with Medications: Spermidine supplementation may interact with certain medications, including those for blood pressure, diabetes, or antiplatelet drugs. It's crucial to consult with a healthcare professional if you are taking any medications to determine if there are any potential interactions.

How does supplementing spermidine help stop aging? 

The idea that supplementing spermidine can help slow down the aging process is based on preliminary scientific research and is still an area of ongoing investigation. While spermidine's potential anti-aging effects have been observed in laboratory studies and animal models, its exact mechanisms are not yet fully understood. Here are some proposed ways in which spermidine supplementation may potentially impact aging:

  1. Autophagy Induction: Spermidine has been found to induce autophagy, a cellular recycling process that helps remove damaged or dysfunctional components and maintain cellular health. By promoting autophagy, spermidine may help eliminate cellular debris and improve the overall health and functionality of cells.

  2. Mitochondrial Health: Spermidine has shown the ability to improve mitochondrial function, which are the energy-producing structures within cells. Enhanced mitochondrial function may contribute to increased cellular energy production, reduced oxidative stress, and improved overall cellular health, potentially slowing down the aging process.

  3. Anti-oxidative and Anti-inflammatory Effects: Spermidine exhibits antioxidant properties, helping to neutralize harmful free radicals and reduce oxidative stress. It may also have anti-inflammatory effects, modulating inflammatory pathways in the body. By reducing oxidative stress and inflammation, spermidine may help protect cells from damage and support healthy aging.

  4. Cardiovascular Health: Spermidine has shown promise in preclinical studies for its potential cardiovascular benefits. It may help improve cardiac function, reduce arterial stiffness, and lower blood pressure, which are factors associated with aging-related cardiovascular decline.

  5. Longevity Studies: Several studies conducted on various organisms, such as yeast, worms, flies, and mice, have suggested that spermidine supplementation could extend lifespan and improve healthspan. These studies have observed improved health outcomes, reduced age-related diseases, and increased survival rates in these organisms.

However, it's important to note that while these findings are promising, more research is needed to fully understand the effects of spermidine supplementation in humans, including the optimal dosages, long-term safety, and potential interactions with other medications or health conditions.

If you're interested in spermidine supplementation for potential anti-aging benefits, it's advisable to consult with a healthcare professional or a qualified specialist who can provide personalized advice based on the latest scientific research and your individual health circumstances.

You may also like